What are the new Hep C treatments?

Since March 2016, a range of new and much improved medicines known as direct-acting antivirals (DAAs) have become available on the Pharmaceutical Benefits Scheme (PBS) in Australia. 

These new medicines offer a cure for most people and have few or no side-effects.

The following DAA medicines are available on the PBS for the treatment of hep C.They are available on prescription from your GP, specialist or authorised practitioner.

Direct-acting antiviral medicines available on the PBS from 1 April 2019 are as follows:

  • Daklinza® (daclatasvir)

  • Epclusa® (sofosbuvir + velpatasvir)

  • Harvoni® (sofosbuvir + ledipasvir)

  • Maviret® (glecaprevir/pibrentasvir)

  • Sovaldi® (sofosbuvir)

  • VOSEVI® (sofosbuvir with velpatasvir and voxilaprevir)*

  • Zepatier® (elbasvir + grazoprevir)

Some of these medicines treat all genotypes (strains) and others are suitable for particular genotypes. 

The DAA medicine or combination of medicines your doctor prescribes for you will depend on a number of things. These include: the genotype of hep C you have, whether you have developed cirrhosis (liver scarring) or whether you have other existing health conditions

*only used as a re-treatment option for 12 weeks in people who are not cured using an NS5A inhibitor

Why are the new treatments better than the old ones?

  • They are much more effective, more people than before are now being cured of hep C

  • Treatment time is shorter

  • They have few or no side effects

  • Your GP, specialist or authorised nurse practitioner can prescribe them

  • They are tablets taken orally with no need for injections

How effective are the new treatment at curing Hep C?

The new treatments have a cure rate above 95%. More people than ever are being cured of hep C.

How long do you need to be on treatment?

Treatment will usually be for a period of 8 to 12 weeks, but may be for up to 24 weeks for some people with liver damage. The amount of time you need to be on treatment will be depend on your own personal situation.

What are the treatment side-effects?

All medicines can have side-effects and each person’s experience will be different. The new DAA medicines have far fewer side-effects and are better tolerated than the older medicines. If you do experience side-effects they may include fatigue, headache, insomnia and nausea, but they are uncommon and typically mild. Please discuss possible side-effects with your doctor.


For more information on hep C treatment you can contact the National Hepatitis Info Line on 1800 437 222.